Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 21, Pages 6192-6195Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.005
Keywords
Hypoxia; Inhibition; Mass spectrometry; 2-Oxoglutarate; Prolyl hydroxylase domain 2
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Funding
- Newton-Abraham Fund
- Rhodes Trust
- Commonwealth Scholarship Scheme
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
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Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2. (c) 2009 Elsevier Ltd. All rights reserved.
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