Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 36, Issue 3, Pages 569-575Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X15615875
Keywords
Blood-brain barrier opening; intra-arterial; mannitol; MRI
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Funding
- Sheik Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center, Children's Research Institute, Washington, DC
- Scholar Award in Neuroradiology Research, The Foundation of the American Society of Neuroradiology (MP)
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Interventional neuroradiology techniques are minimally invasive and allow for superselective drug delivery to specific brain regions. The passage of most agents, however, is impaired by the blood-brain barrier (BBB). Despite its discovery over 40 years ago, hyperosmotic BBB opening (BBBO) remains highly variable, preventing its widespread implementation. Here, we report on a technique that enables the prediction and optimization of the BBBO territory. We found that the microcatheter tip position and the speed of hyperosmolar mannitol injection, both major determinants of the targeted territory, can be modulated in real-time as guided by trans-catheter perfusion MRI.
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