Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 21, Pages 6009-6013Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.062
Keywords
Reactive oxygen species; Antioxidant; Ischemia; Quercetin 3-O-methyl ether; Glucose; Neuroprotection
Categories
Funding
- Plant Diversity Research Center of the 21st Century Frontier Research Program [PF06216-00]
Ask authors/readers for more resources
Due to high reactivity, reactive oxygen species can attack biological molecules leading to cell or tissue injury. In this study, glucose moiety was attached at the C-7 position of quercetin 3-O-methyl ether (1) and luteolin (2) through glycosidic bond or ether linkage. The glucose-containing compounds showed potent DPPH and superoxide anion radical scavenging and lipid peroxidation inhibition activities and nearly equivalent protective actions to the parent aglycons against the H2O2-induced oxidative neuronal damage in primary cultured rat cortical cells. Among the compounds tested, 3b and 3c were the most potent (IC50 values = 7.33 and 5.34 mu M, respectively), exhibiting nearly equivalent actions to the parent compounds 1 and 2 (IC50 = 3.50 and 3.75 mu M, respectively). (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available