Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 15, Pages 4139-4142Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.06.003
Keywords
Bisintercalator; Dinuclear Iron(III) complex; Artificial nuclease
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Funding
- Ministry of Education of China [707016]
- National Natural Science Foundation of China [20706008, 20725621]
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Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage. (C) 2009 Elsevier Ltd. All rights reserved.
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