Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 35, Issue 7, Pages 1076-1084Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2015.84
Keywords
camera imaging; laser speckle contrast imaging; laser speckle flowmetry; optical imaging
Categories
Funding
- National Institutes of Health [EB011556, NS078791, NS082518]
- Coulter Foundation
- American Heart Association [14EIA8970041]
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Laser speckle contrast imaging (LSCI) provides a rapid characterization of cortical flow dynamics for functional monitoring of the microcirculation. The technique stems from interactions of laser light with moving particles. These interactions encode the encountered Doppler phenomena within a random interference pattern imaged in widefield, known as laser speckle. Studies of neurovascular function and coupling with LSCI have benefited from the real-time characterization of functional dynamics in the laboratory setting through quantification of perfusion dynamics. While the technique has largely been relegated to acute small animal imaging, its scalability is being assessed and characterized for both chronic and clinical neurovascular imaging.
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