4.5 Article

Identification of Hsp70 modulators through modeling of the substrate binding domain

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 14, Pages 3828-3831

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.062

Keywords

HSP-70; Multi component reaction; Ugi reaction; Isocyanide; Protein protein interaction; Modulator; Peptide recognition site

Funding

  1. NIGMS NIH HHS [R01 GM075061] Funding Source: Medline

Ask authors/readers for more resources

The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology. (C) 2009 Published by Elsevier Ltd.

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