Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 11, Pages 2920-2923Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.076
Keywords
CK2; Crystal structure; Structure-based drug design; Ellagic acid
Categories
Funding
- National Institute of Biomedical Innovation (NIBIO)
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We determined the 2.35-angstrom crystal structure of a human CK2 catalytic subunit (referred to as CK2 alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2 alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.
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