Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 15, Pages 4217-4222Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.05.107
Keywords
Ras protein; Sugars; Synthesis; Anticancer agents; NMR; Molecular modeling
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Funding
- NIDDK NIH HHS [DK46371] Funding Source: Medline
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By combining in the same molecule Ras-interacting aromatic moieties and a sugar, we prepared a water-soluble Ras ligand that binds Ras and inhibits guanine nucleotide exchange. With this compound it was possible to determine experimentally by a N-15-edited HSQC NMR experiment the ligand-Ras binding interface. (C) 2009 Elsevier Ltd. All rights reserved.
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