Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II

Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the. ling process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (2-4). (C) 2009 Elsevier Ltd. All rights reserved.