Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 10, Pages 2627-2629Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.018
Keywords
PNP inhibitor; T-cell proliferation
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Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the. ling process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (2-4). (C) 2009 Elsevier Ltd. All rights reserved.
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