Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 14, Pages 3856-3858Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.152
Keywords
beta,gamma-Unsaturated alpha-amino acids; Modified cinchona alkaloids; Asymmetric synthesis; Catalysis; Kinetic resolution; Dynamic kinetic resolution
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Funding
- NIH [GM-61591]
- Daiso
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The beta,gamma-unsaturated amino acids are versatile chiral building blocks and biologically interesting compounds. The asymmetric synthesis of beta,gamma-unsaturated amino acids presents a challenging task as these compounds are labile toward racemization as well as the undesirable double bond isomerization. An efficient, general and mild kinetic resolution with readily accessible and fully recyclable cinchona alkaloid catalysts has been developed to provide a reliably useful approach toward optically active beta,gamma-unsaturated amino acids. (C) 2009 Elsevier Ltd. All rights reserved.
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