Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 22, Pages 6303-6306Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.093
Keywords
Anticancer activity; Deoxoartemisinin; Non-acetal type; Antiangiogenesis
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Funding
- Ministry of Health & Welfare, Republic of Korea [A084166]
- Ministry of Education and Human Resources Development, the Republic of Korea
- Korea Health Promotion Institute [A084166] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay. (C) 2009 Elsevier Ltd. All rights reserved.
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