4.5 Article

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 15, Pages 4241-4244

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.05.097

Keywords

FAAH, fatty acid amide hydrolase; Azetidine; Urea; Inhibitor

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We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase ( FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1. (C) 2009 Elsevier Ltd. All rights reserved.

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