Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 2, Pages 341-343Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.11.082
Keywords
Cinnamic derivatives; Antituberculosis agents; Mycobacterium tuberculosis; TB MIC
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Funding
- CNRS
- 'Universite Paul Sabatier'
- European Commission [LSHP-CT-2005-018923]
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In an effort to develop potent new antituberculous drugs effective against Mycobacterium tuberculosis, we have prepared series of cinnamic derivatives (thioesters and amides) with 4-hydroxy and 4-alkoxy groups and investigated the in vitro activities of these compounds. Among them some displayed a good in vitro antibacterial activity, such as (E)-N-(2-acetamidoethyl)-3-{4-[(E)-3,7-dimethylocta-2,6-dienyloxy]phenyl} acrylamide 4b that showed a minimum inhibitory concentration of 0.1 mu g/mL (0.26 mu M) against M. tuberculosis H37Rv. (C) 2008 Elsevier Ltd. All rights reserved.
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