Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 3, Pages 828-830Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.12.006
Keywords
Potential inhibitors; DNA topoisomerase II; alpha-Lapachone; Microwave irradiation
Categories
Funding
- National Science Foundation of China [20672090]
- Natural Science Foundation of the Jiangsu Province [BK2006033]
- Jiangsu Province [06-A-039]
- Xuzhou Normal University [08YLB028]
Ask authors/readers for more resources
A new series of potential inhibitors of DNA topoisomerase II were synthesized from facile materials (aromatic aldehydes, Meldrum's acid and 2-hydroxynaphthalene-1,4-dione) under microwave irradiation. The method provides a valuable tool in designing new and more potent cytotoxic analogues. This procedure is advantageous both economically and environmentally. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
