Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 19, Pages 5675-5678Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.08.007
Keywords
Cannabinoid CB1; Antagonist; Inverse agonist; Scaffold hopping; Tetrahydropyridazine
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The synthesis and structure-activity relationship studies of 1,4,5,6-tetrahydropyridazines are described. The target compounds 3-5 represent a novel class of potent and selective CB1 receptor antagonists. (C) 2009 Elsevier Ltd. All rights reserved.
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