Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 9, Pages 2562-2565Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.045
Keywords
Hedychium spicatum; Labdane-type diterpenes; Spicatanol; Spicatanol methyl ether; Antihyperglycemic activity; alpha-Glucosidase inhibitory activity
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Funding
- DST-IMPCL
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Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential. (C) 2009 Elsevier Ltd. All rights reserved.
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