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Scott Ayton et al.
BIOMED RESEARCH INTERNATIONAL (2014)
Modulation of tau phosphorylation by environmental copper
Kellen Voss et al.
TRANSLATIONAL NEURODEGENERATION (2014)
Probing copper/tau protein interactions electrochemically
Sanela Martic et al.
ANALYTICAL BIOCHEMISTRY (2013)
Apigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model
Le Zhao et al.
BRAIN RESEARCH (2013)
Metallostasis in Alzheimer's disease
Scott Ayton et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Role of Metal Ions in the Self-assembly of the Alzheimer's Amyloid-β Peptide
Peter Faller et al.
INORGANIC CHEMISTRY (2013)
Longitudinal Analysis of Serum Copper and Ceruloplasmin in Alzheimer's Disease
Alan Rembach et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Bis(thiosemicarbazone) copper complexes: mechanism of intracellular accumulation
Catherine Lambert et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2013)
Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts
Raja Bhattacharyya et al.
JOURNAL OF NEUROSCIENCE (2013)
A RANDOMIZED CONTROLLED ALZHEIMER'S DISEASE PREVENTION TRIAL'S EVOLUTION INTO AN EXPOSURE TRIAL: THE PREADVISE TRIAL
R. J. Kryscio et al.
JOURNAL OF NUTRITION HEALTH & AGING (2013)
Diagnostic Imaging Agents for Alzheimer's Disease: Copper Radiopharmaceuticals that Target Aβ Plaques
James L. Hickey et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms
Minglin Lang et al.
NEUROBIOLOGY OF AGING (2013)
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation
Yan Xiong et al.
NEUROBIOLOGY OF AGING (2013)
Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease
Chuang Guo et al.
NEUROBIOLOGY OF AGING (2013)
Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain
Chuang Guo et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
Elevated amyloid-beta plaque deposition in dietary selenium-deficient Tg2576 transgenic mice
Mamoru Haratake et al.
METALLOMICS (2013)
Presenilin Promotes Dietary Copper Uptake
Adam Southon et al.
PLOS ONE (2013)
Altered Expression of ZnT10 in Alzheimer's Disease Brain
Helen J. Bosomworth et al.
PLOS ONE (2013)
Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease
Sanghamitra Bandyopadhyay et al.
PLOS ONE (2013)
The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer's disease
Raj C. Shah et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
Effects of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and Alzheimer's and Parkinson's diseases
S. Mariani et al.
FRONTIERS IN AGING NEUROSCIENCE (2013)
A delicate balance: Iron metabolism and diseases of the brain
Dominic Hare et al.
FRONTIERS IN AGING NEUROSCIENCE (2013)
Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis
Erin J. McAllum et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2013)
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease
Animesh Alexander Raha et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2013)
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon et al.
CELL (2012)
Neuroprotective Effects of Low-dose Lithium in Individuals at Ultra-high Risk for Psychosis. A Longitudinal MRI/MRS Study
Gregor E. Berger et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Elevated labile Cu is associated with oxidative pathology in Alzheimer disease
Simon A. James et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain
Si-Eun Yoo et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Brain Burdens of Aluminum, Iron, and Copper and their Relationships with Amyloid-β Pathology in 60 Human Brains
Christopher Exley et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Zinc Transporter mRNA Levels in Alzheimer's Disease Postmortem Brain
Nancy Beyer et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Overexpression of Human Wild-Type Amyloid-β Protein Precursor Decreases the Iron Content and Increases the Oxidative Stress of Neuroblastoma SH-SY5Y Cells
Li Wan et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A)
Xu-Ying Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease
Lin W. Hung et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
Peng Lei et al.
NATURE MEDICINE (2012)
Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project
Donald J. Lehmann et al.
NEUROBIOLOGY OF AGING (2012)
Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake
Ling Xie et al.
NEUROCHEMISTRY INTERNATIONAL (2012)
High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: Quantitative imaging and correlation with iron
Vijay Antharam et al.
NEUROIMAGE (2012)
Long-term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AßPP and AßPP/tau transgenic mice
Haruhiko Akiyama et al.
NEUROPATHOLOGY (2012)
Zinc diet and Alzheimer's disease: a systematic review
Martin Loef et al.
NUTRITIONAL NEUROSCIENCE (2012)
Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease
Travis J. A. Craddock et al.
PLoS One (2012)
The PICALM Protein Plays a Key Role in Iron Homeostasis and Cell Proliferation
Paula B. Scotland et al.
PLOS ONE (2012)
Copper Chelator Induced Efficient Episodic Memory Recovery in a Non-Transgenic Alzheimer's Mouse Model
Johnatan Ceccom et al.
PLOS ONE (2012)
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice
J. M. Fine et al.
EXPERIMENTAL BRAIN RESEARCH (2012)
Copper(II) Coordination to Amyloid beta: Murine versus Human Peptide
Helene Eury et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability
Haiqing Hua et al.
BIOLOGICAL CHEMISTRY (2011)
Glutathione: a key component of the cytoplasmic labile iron pool
Robert C. Hider et al.
BIOMETALS (2011)
Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease
Alessandra Gaeta et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
pH-Dependent Cu(II) Coordination to Amyloid-β Peptide: Impact of Sequence Alterations, Including the H6R and D7N Familial Mutations
Bruno Alies et al.
INORGANIC CHEMISTRY (2011)
Iron(II) Binding to Amyloid-β, the Alzheimer's Peptide
Fatima Bousejra-ElGarah et al.
INORGANIC CHEMISTRY (2011)
Free Copper Distinguishes Mild Cognitive Impairment Subjects from Healthy Elderly Individuals
Rosanna Squitti et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Copper in Alzheimer's Disease: A Meta-Analysis of Serum, Plasma, and Cerebrospinal Fluid Studies
Serena Bucossi et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Copper Promotes the Trafficking of the Amyloid Precursor Protein
Karla M. Acevedo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation
Beinan Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity
Mark A. Greenough et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Cu(II) Mediates Kinetically Distinct, Non-amyloidogenic Aggregation of Amyloid-β Peptides
Jeppe T. Pedersen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Biphasic effects of copper on neurotransmission in rat hippocampal neurons
Christian Peters et al.
JOURNAL OF NEUROCHEMISTRY (2011)
The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity
Peter J. Crouch et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Copper Reduces Aβ Oligomeric Species and Ameliorates Neuromuscular Synaptic Defects in a C. elegans Model of Inclusion Body Myositis
Daniela L. Rebolledo et al.
JOURNAL OF NEUROSCIENCE (2011)
Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
Andreas M. Grabrucker et al.
MOLECULAR NEURODEGENERATION (2011)
Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse
Enhui Pan et al.
NEURON (2011)
Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway
Insook Kim et al.
NEUROREPORT (2011)
Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease
Paul A. Adlard et al.
PLOS ONE (2011)
Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion
Matthew Schrag et al.
PROGRESS IN NEUROBIOLOGY (2011)
Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease
Min-Hyuk Yoo et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain
Joo-Yong Lee et al.
BIOMETALS (2010)
Alterations of Zinc Transporter Proteins ZnT-1, ZnT-4 and ZnT-6 in Preclinical Alzheimer's Disease Brain
Ganna Lyubartseva et al.
BRAIN PATHOLOGY (2010)
Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives
Nathalie Arnal et al.
BRAIN RESEARCH (2010)
Nutritional status of selenium in Alzheimer's disease patients
Barbara Rita Cardoso et al.
BRITISH JOURNAL OF NUTRITION (2010)
Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
James A. Duce et al.
CELL (2010)
Alpha-Tocopherol Decreases Iron-Induced Hippocampal and Nigral Neuron Loss
M. Oemer Bostanci et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2010)
Copper Transfer from Cu-Aβ to Human Serum Albumin Inhibits Aggregation, Radical Production and Reduces Aβ Toxicity
Lorena Perrone et al.
CHEMBIOCHEM (2010)
A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques
SinChun Lim et al.
CHEMICAL COMMUNICATIONS (2010)
Lipofuscin-bound iron is a major intracellular source of oxidants: Role in senescent cells
Annika Hoehn et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
A Copper-Lowering Strategy Attenuates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease
Joseph F. Quinn et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-beta Production
Emma H. Gray et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses
Noel G. Faux et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Bis(thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease
Michelle T. Fodero-Tavoletti et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model
Niall M. Corcoran et al.
JOURNAL OF CLINICAL NEUROSCIENCE (2010)
Altered microglial copper homeostasis in a mouse model of Alzheimer's disease
Zhiqiang Zheng et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex
Mubeen A. Ansari et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?
Paul A. Adlard et al.
JOURNAL OF NEUROSCIENCE (2010)
A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation
Drew S. Folk et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Case-control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: A short review
Gudlaug Torsdottir et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2010)
Selenium attenuates Aβ production and Aβ-induced neuronal death
A-Ryeong Gwon et al.
NEUROSCIENCE LETTERS (2010)
Zinc Overload Enhances APP Cleavage and Aβ Deposition in the Alzheimer Mouse Brain
Chun-Yan Wang et al.
PLOS ONE (2010)
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models
Janet van Eersel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states
Yifat Miller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-β copper complex follow a preorganization mechanism
Veronique Balland et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction
C. Corona et al.
CELL DEATH & DISEASE (2010)
Pulse EPR Spectroscopy Reveals the Coordination Sphere of Copper(II) Ions in the 1-16 Amyloid-beta Peptide: A Key Role of the First Two N-Terminus Residues
Pierre Dorlet et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Cellular Copper Import by Nanocarrier Systems, Intracellular Availability, and Effects on Amyloid β Peptide Secretion
Carina Treiber et al.
BIOCHEMISTRY (2009)
Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type
Tauheed Ishrat et al.
BRAIN RESEARCH (2009)
Inhibition of glycogen synthase kinase-3β downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A
Ludovic Martin et al.
BRAIN RESEARCH (2009)
Chronic Exposure to High Levels of Zinc or Copper has Little Effect on Brain Metal Homeostasis or Aβ Accumulation in Transgenic APP-C100 Mice
Christa J. Maynard et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2009)
Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer's disease
Thomas Rival et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2009)
Divalent metal transporter 1 is involved in amyloid precursor protein processing and A beta generation
Wei Zheng et al.
FASEB JOURNAL (2009)
The Effects of Enhanced Zinc on Spatial Memory and Plaque Formation in Transgenic Mice
David H. Linkous et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Clioquinol Decreases Amyloid-beta Burden and Reduces Working Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease
Cristina Grossi et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322
Zhong-Ying Mo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains
Janet van Eersel et al.
JOURNAL OF NEURAL TRANSMISSION (2009)
Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD
Masashi Kitazawa et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators
Vello Tougu et al.
JOURNAL OF NEUROCHEMISTRY (2009)
A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses
Atul Deshpande et al.
JOURNAL OF NEUROSCIENCE (2009)
Small Molecule Modulators of Copper-Induced Aβ Aggregation
Sarmad S. Hindo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial (vol 7, pg 779, 2008)
L. Lannfelt et al.
LANCET NEUROLOGY (2009)
Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification
Alicia N. Minniti et al.
MOLECULAR NEURODEGENERATION (2009)
Zinc and copper modulate Alzheimer Aβ levels in human cerebrospinal fluid
Dorothea Strozyk et al.
NEUROBIOLOGY OF AGING (2009)
HFE variants, APOE and Alzheimer's disease: Findings from the population-based Rotterdam Study
B. Z. Alizadeh et al.
NEUROBIOLOGY OF AGING (2009)
Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease
Andreana C. Leskovjan et al.
NEUROIMAGE (2009)
DISTRIBUTION AND PROGRESSION OF AMYLOID-β DEPOSITS IN THE AMYGDALA OF THE AGED MACAQUE MONKEY, AND PARALLELS WITH ZINC DISTRIBUTION
N. Ichinohe et al.
NEUROSCIENCE (2009)
Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
Peter J. Crouch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Intracellular copper deficiency increases amyloid-ß secretion by diverse mechanisms
Michael A. Cater et al.
BIOCHEMICAL JOURNAL (2008)
Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease
Jack T. Rogers et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-Mediated cell death
Alexander Seiler et al.
CELL METABOLISM (2008)
Metals in Alzheimer's and Parkinson's diseases
Kevin J. Barnham et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents
Wei-hui Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
Holger Kessler et al.
JOURNAL OF NEURAL TRANSMISSION (2008)
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Aβ
Paul A. Adlard et al.
NEURON (2008)
Lithium down-regulates tau in cultured cortical neurons: A possible mechanism of neuroprotection
A. Rametti et al.
NEUROSCIENCE LETTERS (2008)
Selective intracellular release of copper and zinc ions from bis( thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-β peptide
Paul S. Donnelly et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease:: a phase IIa, double-blind, randomised, placebo-controlled trial
Lars Lannfelt et al.
LANCET NEUROLOGY (2008)
Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency
M. Stoltenberg et al.
NEUROSCIENCE (2007)
Genes related to iron metabolism and susceptibility to Alzheimer's disease in Basque population
L. Blazquez et al.
NEUROBIOLOGY OF AGING (2007)
Three histidine residues of amyloid-β peptide control the redox activity of copper and iron
M. Nakamura et al.
BIOCHEMISTRY (2007)
Redox reactions of copper complexes formed with different β-amyloid peptides and their neuropathalogical relevance
Dianlu Jiang et al.
BIOCHEMISTRY (2007)
Mechanism of copper(II) inhibiting Alzheimer's amyloid β-peptide from aggregation:: A molecular dynamics investigation
Yong Jiao et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2007)
Hydrogen peroxide can be generated by tau in the presence of Cu(II)
Xiao-Yang Su et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin
Ivana De Domenico et al.
EMBO JOURNAL (2007)
Metal ions differentially influence the aggregation and deposition of Alzheimer's β-amyloid on a solid template
Chanki Ha et al.
BIOCHEMISTRY (2007)
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias
Shino Magaki et al.
NEUROSCIENCE LETTERS (2007)
Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-β peptide
David P. Smith et al.
BIOCHEMISTRY (2007)
Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity
Michelle L. Schlief et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Protective effect of N-acetyl-L-cysteine on amyloid β-peptide-induced learning and memory deficits in mice
Ai-Ling Fu et al.
BRAIN RESEARCH (2006)
Distinct early folding and aggregation properties of Alzheimer amyloid-β peptides Aβ40 and Aβ42 -: Stable trimer or tetramer formation by Aβ42
Yun-Ru Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
NMR reveals anomalous copper(II) binding to the amyloid Aβ peptide of Alzheimer's disease
Liming Hou et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Elevated cortical zinc in Alzheimer disease
D. Religa et al.
NEUROLOGY (2006)
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in Alzheimer's disease
Lisa M. Miller et al.
JOURNAL OF STRUCTURAL BIOLOGY (2006)
Gender and genetic background effects on brain metal levels in APP transgenic and normal mice:: Implications for Alzheimer β-amyloid pathology
Christa J. Maynard et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2006)
Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS
QF Ma et al.
PEPTIDES (2006)
Redox cycling of iron by Aβ42
A Khan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
P70S6 kinase mediates tau phosphorylation and synthesis
JJ Pei et al.
FEBS LETTERS (2006)
4-hydroxynonenal disrupts zinc export in primary rat cortical cells
JL Smith et al.
NEUROTOXICOLOGY (2006)
Molecular modeling of the inhibitory mechanism of copper(II) on aggregation of amyloid β-peptide
Y Jiao et al.
SCIENCE IN CHINA SERIES B-CHEMISTRY (2005)
In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
DE Hoke et al.
FEBS JOURNAL (2005)
Alzheimer disease β-amyloid activity mimics cholesterol oxidase
L Puglielli et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Methionine regulates copper/hydrogen peroxide oxidation products of Aβ
FE Ali et al.
JOURNAL OF PEPTIDE SCIENCE (2005)
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH-SY5Y neuroblastoma cells
WL An et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Zinc-specific autometallographic in vivo selenium methods: Tracing of zinc-enriched (ZEN) terminals, ZEN pathways, and pools of zinc ions in a multitude of other ZEN cells
G Danscher et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2005)
Copper binding to the amyloid-β (Aβ) peptide associated with Alzheimer's disease -: Folding, coordination geometry, pH dependence, stoichiometry, and affinity of Aβ-(1-28):: Insights from a range of complementary spectroscopic techniques
CD Syme et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease
AL Friedlich et al.
JOURNAL OF NEUROSCIENCE (2004)
Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
JY Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Neurodegenerative diseases and oxidative stress
KJ Barnham et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Copper mediates dityrosine cross-linking of Alzheimer's amyloid-β
CS Atwood et al.
BIOCHEMISTRY (2004)
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β-amyloid
KJ Barnham et al.
FASEB JOURNAL (2004)
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Aβ peptides
XD Huang et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2004)
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase - Modulation by zinc
FM Harris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Enhanced toxicity and cellular binding of a modified amyloid β peptide with a methionine to valine substitution
GD Ciccotosto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Copper depletion down-regulates expression of the Alzheimer's disease amyloid-β precursor protein gene
SA Bellingham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts
SA Bellingham et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice
TA Bayer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
In vivo reduction of amyloid-β by a mutant copper transporter
AL Phinney et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
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