Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 8, Pages 2168-2171Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.02.107
Keywords
2-Cyano-28-hydroxy-lup-1-en-3-one; Triterpenoid; Betulinic acid; Betulin; Cytotoxicity
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New A-ring modified betulin and dihydrobetulin derivatives possessing the 2-cyano-1-en-3-one moiety were prepared and tested for cytotoxicity in seven cancer cell lines. The most active agent 9a synthesized in this account was further demonstrated to induce apoptosis and to activate caspases in malignant melanoma cells. (C) 2009 Elsevier Ltd. All rights reserved.
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