Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 14, Pages 3725-3728Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.05.058
Keywords
Polyglycerol; Polymer therapeutics; Prodrug; Doxorubicin; Methotrexate; Drug conjugate; Controlled release; Nanocarrier
Categories
Funding
- Ministry of Science [BMBF 03X5501]
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In this Letter we report the synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented. (C) 2009 Elsevier Ltd. All rights reserved.
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