Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 3, Pages 619-626Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob02383c
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Funding
- National Natural Science Foundation of China [21672028]
- Qing Lan Project of Jiangsu Province
- Jiangsu Key Laboratory of Advanced Catalytic Materials Technology [BM2012110]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [SJCX20_1035]
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A metal-free oxidative radical methylation/arylation of 2-arylbenzoimidazoles has been developed, leading to a series of methyl functionalized benzimidazo[2,1-a]isoquinoline-6(5H)-ones in moderate to good yields. Additionally, ethylation/arylation of 2-arylbenzoimidazoles was also achieved using DTAP.
A metal-free oxidative radical methylation/arylation of 2-arylbenzoimidazoles with DTBP as the oxidant and methyl radical source was developed. The reaction proceeds through a sequential methyl radical addition/cyclization pathway and affords a series of methyl functionalized benzimidazo[2,1-a]isoquinoline-6(5H)-ones in moderate to good yields. Besides, the ethylation/arylation of 2-arylbenzoimidazoles was also achieved with DTAP.
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