Synthesis and antitubercular activity of 7-chloro-4-quinolinylhydrazones derivatives

A series of twenty-one 7-chloro-4-quinolinylhydrazones (3a-u) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The compounds 3f, 3i and 3o were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity (2.5 mu g/mL), which can be compared with that of the first line drugs, ethambutol (3.12 mu g/mL) and rifampicin (2.0 mu g/mL). These results can be considered an important start point for the rational design of new leads for anti-TB compounds. (C) 2009 Elsevier Ltd. All rights reserved.