Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 22, Pages 6289-6292Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.092
Keywords
Tetrahydronaphthalene-1-ol (TNO) analogs; Tetrahydroneotanshinlactone (TNT) analogs; Cytotoxicity; Breast cancer
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Funding
- National Cancer Institute [CA-17625]
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Tetrahydroneotanshinlactone (TNT) and tetrahydronaphthalene-1-ol (TNO) derivatives were designed, synthesized, and evaluated for cytotoxic activity. The TNO derivatives were found to be a promising novel class of in vitro antitumor agents. The cyclohexene ring-A could dramatically affect the antitumor activity and selectivity. Compound 20 showed the highest potency with ED50 values of 0.7 and 1.7 mu M against SK-BR-3 and ZR-75-1 breast cancer cell lines, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
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