Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 23, Pages 6655-6658Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.10.007
Keywords
Chitooligosaccharides; Lipopolysaccharide; Cyclooxygenase-2; Inducible nitric oxide synthase; Cytokines
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Funding
- Korean Government [KRF-2008-331-F00070]
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In this study, factors affecting anti-inflammatory effect of chitooligosaccharides (COSs) in lipopolysaccharides (LPS)-induced RAW264.7 macrophage cells were investigated. The inhibition of NO secretion by COSs revealed that 90-COSs (90% N-deacetylation) significantly inhibited NO secretion than those of 50-COSs (50% N-deacetylation), and 90-HMWCOS (5000-10,000 Da) in the 90-COSs showed the highest inhibition activity. Furthermore, 90-HMWCOSs also found to inhibit LPS-stimulated production of PGE(2), TNF-alpha and IL-6, as well as the expression of iNOS, COX-2, TNF-alpha, and IL-6. These results suggested that 90-HMWCOS may have anti-inflammatory effect via down-regulation of transcriptional and translational expression levels of TNF-alpha, IL-6 and iNOS and COX-2. (C) 2009 Elsevier Ltd. All rights reserved.
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