Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 19, Issue 7, Pages 1851-1854Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.02.082
Keywords
Benzofuran; Angiogenesis; HUVEC proliferation
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Funding
- Knowledge Innovation Program of Chinese Academy of Sciences [KSCX-2-YW-R-22]
- National Basic Research Program of China [2007CB914504]
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A series of benzofuran derivatives were synthesized and evaluated against HUVEC proliferation. Among these compounds, compound 32 exhibited good inhibitory activity and remarkable selectivity to HUVEC. Our current data suggested that array order of methyl, acrylate and carboxylate groups in benzofuran scaffold is the basic requirement for inhibitory activity against HUVEC proliferation. These results demonstrated that benzofuran scaffold represents a promising structural core to discover a new class of active and selective angiogenesis inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.
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