Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 9, Pages 2952-2956Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.03.065
Keywords
drug targeting; amphotericin B; controlled release in vitro
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A new targeting potentially intravenous conjugate Amphotericin B (AMB)-star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a beta-D-glucopyranoside molecular switch which is sensitive to beta-glucosidases (E. C. 3.2.1.21). The beta-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC. (C) 2008 Elsevier Ltd. All rights reserved.
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