Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 15, Pages 4438-4441Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.06.026
Keywords
coactivator associated arginine; methyltransferase 1; CARM1; PRMT4; protein arginine methyltransferase
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This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1. (c) 2008 Elsevier Ltd. All rights reserved.
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