Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 21, Pages 5774-5776Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.09.072
Keywords
Chitosan oligosaccharide; Carboxymethyl chitosan oligosaccharide; Substituting degree; Antioxidant activity; Reducing power
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Funding
- Shanghai Leading Academic Discipline [T1102]
- Shanghai Commission of Education Scientific Research [07zz134]
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Three N-carboxymethyl chitosan oligosaccharides (N-CMCOSs) with different degrees of substitution (NA: 0.28, NB: 0.41, and NC: 0.54, respectively) were prepared by the control of the amount of glyoxylic acid in the etherification process of chitosan oligosaccharide (COS). Their antioxidant activities were evaluated by the scavenging of 1,1-diphenyl-2-picrylhrazyl radical (DPPH) radical, superoxide anion and determination of reducing power. With the increasing of substituting degree, the scavenging activity of N-CMCOSs against DPPH radical decreased and reducing power increased. As for superoxide anion scavenging, the order is NB > NC > NA. The difference may be related to the different radical scavenging mechanisms and donating effect of substituting carboxymethyl group. (C) 2008 Published by Elsevier Ltd.
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