Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 7, Pages 2434-2439Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.02.047
Keywords
pyrrolo[2,1-c][1,4] benzodiazepines; chalcones; DNA-binding; affinity; anticancer activity; aza-Wittig reductive cyclization
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A new class of C8-linked pyrrolo[2,1-c][1,4] benzodiazepine-chalcone conjugates have been prepared by employing a solid-phase synthetic protocol. In this strategy an intramolecular aza-Wittig reductive cyclization approach has been utilized. Interestingly, some of these molecules have shown enhanced DNA-binding affinity and promising anticancer activity on a large number of human cancer cell lines. (C) 2008 Elsevier Ltd. All rights reserved.
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