Journal
JOURNAL OF VIROLOGY
Volume 95, Issue 2, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01381-19
Keywords
inflammation; pregnancy; viral infection
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Funding
- NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [R01HD097608, R21HD099000]
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Viral infections during pregnancy can lead to a range of maternal and fetal outcomes, understanding the mechanisms of viral pathogens and maternal immune responses may help prevent adverse pregnancy outcomes.
Viral infections during pregnancy lead to a spectrum of maternal and fetal outcomes, ranging from asymptomatic disease to more critical conditions presenting with severe maternal morbidity, stillbirth, preterm birth, intrauterine growth restriction, and fetal congenital anomalies, either apparent at birth or later in life. In this article, we review the pathogenesis of several viral infections that are particularly relevant in the context of pregnancy and intrauterine inflammation. Understanding the diverse mechanisms employed by viral pathogens as well as the repertoire of immune responses induced in the mother may help to establish novel therapeutic options to attenuate changes in the maternal-fetal interface and prevent adverse pregnancy outcomes.
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