A novel electrochemical sensor based on TAPT-TFP-COF/COOH-MWCNT for simultaneous detection of dopamine and paracetamol

In this work, a covalent organic framework (COF) TAPT-TFP-COF containing a triazine ring was prepared by a typical Schiff base condensation reaction of 1,3,5-tris-(4-aminophenyl)triazine (TAPT) and 1,3,5-triformyl phloroglucinol (TFP). The TAPT-TFP-COF and carboxyl-functionalized multi-wall carbon nanotubes (COOH-MWCNTs) were drip-coated on glassy carbon electrode respectively to develop a novel and simple electrochemical sensor in order to simultaneously detect dopamine (DA) and paracetamol (PA). COOH-MWCNTs interconnected the TAPT-TFP-COF and acted as bridges between the COF particles, which had a good synergistic effect and accelerated electron transfer. Under optimal conditions, linear responses were obtained over the concentration range 1-190 mu M for DA and PA with limits of detection (LOD) of 0.14 mu M and 0.19 mu M, respectively. Furthermore, the fabricated sensor possesses outstanding repeatability and high selectivity, and can be applied for the determination of DA and PA in dopamine injection and acetaminophen drugs with satisfactory recoveries.

Automated summary

In this study, a novel COF material TAPT-TFP-COF was successfully prepared and utilized in the development of an electrochemical sensor for simultaneous detection of dopamine and paracetamol. The introduction of COOH-MWCNTs significantly improved the sensor performance, showing good linear responses and sensitivity.