Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 6, Pages 2179-2182Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.12.076
Keywords
nitric oxide synthase; cyclooxygenase; Xanthium strumarium; sesquiterpene; nuclear factor kappa B
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Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC50 values: 0.47, 11.2, 136.5 mu M, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappa B through the inhibition of LPS-induced I-kappa B-alpha degradation in microglia. (C) 2008 Elsevier Ltd. All rights reserved.
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