Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 23, Pages 6265-6267Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.09.082
Keywords
Carbohydrates; Glycosyl triazoles; Click chemistry; Arabinose; Mycobacteria; Tuberculosis
Categories
Funding
- EPSRC [D051495/1]
- EPSRC [EP/D051495/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D051495/1] Funding Source: researchfish
Ask authors/readers for more resources
A series of arabino glycosyl triazoles with varying hydrophobic groups were synthesised as putative mimics of decaprenolphosphoarabinose (DPA) as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity, with strong dependence on the identity of the hydrophobic side chain. (C) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
