Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 24, Pages 6968-6970Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.10.086
Keywords
CD1d; iNKT cells; alpha-S-GalCer; KRN7000
Categories
Funding
- NIH NIAID [AI057519, 2RO1 AI 45051, U19 AI046130]
- JDRF [1-2004-771]
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The synthesis and evaluation for iNKT stimulation of alpha-S-galactosylceramide is reported. Prepared by alkylation of a galactosylthiol, this analog of the potent immunostimulatory agent, KRN7000, did not stimulate iNKT cells either in vitro or in vivo. (C) 2008 Elsevier Ltd. All rights reserved.
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