Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 20, Pages 5359-5363Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.09.061
Keywords
ivermectin; combinatorial biosynthesis; polyketide synthase; avermectin; aveC; Streptomyces avermitilis
Categories
Funding
- National Basic Research Program of China [2003CB114205]
- National High Technology Research and Development [2006AA10A209]
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Two new recombinants of avermectin polyketide synthases were constructed by domain and module swapping in Streptomyces avermitilis 73-12. However, only the strain, S. avermitilis OI-31, formed by domain substitution could produce ivermectin. Analysis of the ivermectin synthesized gene cluster showed that decreased amount of aveC transcripts was one of the factors causing low yield of ivermectin. Overexpression of aveC could improve ivermectin yield. (C) 2008 Elsevier Ltd. All rights reserved.
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