Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 17, Pages 4844-4848Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.07.080
Keywords
KDR inhibitor; VEGFR-2 inhibitor; kinase inhibitor
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A novel class of potent and selective inhibitors of KDR incorporating an indazole moiety 1 is reported. The discovery, synthesis, and structure-activity relationships of this series of inhibitors have been investigated. The most promising compounds were also pro. led to determine their pharmacokinetic properties and evaluated in a VEGF-induced vascular permeability assay. (C) 2008 Elsevier Ltd. All rights reserved.
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