Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 14, Pages 3925-3928Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.06.031
Keywords
proyl hydroxylase inhibitors; HIF-1 alpha; hypoxia; ischemia; anemia; peripheral arterial disease; myocardial infarction; stroke; diabetes; hydroxy-thiazole
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Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.
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