Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 7, Pages 2404-2408Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.02.056
Keywords
calmodulin; kinase; inhibitors; pyrimidines
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Non-ATP competitive pyrimidine-based inhibitors of CaMKIId were identified. Computational studies were enlisted to predict the probable mode of binding. The results of the computational studies led to the design of ATP competitive inhibitors with optimized hinge interactions. Inhibitors of this class possessed improved enzyme and cellular activity compared to early leads. (C) 2008 Elsevier Ltd. All rights reserved.
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