Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 24, Pages 6479-6481Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.10.057
Keywords
Calmodulin inhibition; Malbrancheamide; Prenylated indole alkaloid
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Funding
- National Institutes of Health [CA70375]
- Consejo Nacional de Ciencia y Tecnologia (CONACyT) [45814-Q]
- NIH Shared Instrumentation Grant at Colorado State University [GM49631]
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The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified. [GRAPHICS] (C) 2008 Elsevier Ltd. All rights reserved.
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