Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 20, Pages 5463-5465Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.09.035
Keywords
MRI; contrast agent; SPIO; nanoparticle; aptamer; assembly
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Funding
- NEDO (New Energy and Industrial Technology Development Organization)
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We report the direct modification of SPIOs with a biomolecule and the target-specific assembly system of these modified SPIOs for using MRI contrast agents. The transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state. (c) 2008 Elsevier Ltd. All rights reserved.
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