Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 2, Pages 808-811Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.11.030
Keywords
RA-XVIII; deoxybouvardin; cytotoxicity; Rubia cordifolia; synthesis
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A new bicyclic peptide of RA-series, RA-XVIII (3), was isolated from the roots of Rubio cordifolia L. Its structure was established to be a hydroxylated derivative of RA-VII by the semi-synthesis of 3 from deoxybouvardin, and its cytotoxicity against P-388 cells was 0.012 mu g/mL. (c) 2007 Elsevier Ltd. All rights reserved.
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