Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 16, Pages 4688-4691Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.07.001
Keywords
anti-austerity strategy; preferential cytotoxicity; pancreatic cancer; PANC-1; Kayea assamica
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Funding
- Ministry of Health and Welfare
- Ministry of Education, Culture, Sports, Science and Technology, Japan
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The CHCl(3)-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 mu g/mL. Bioassay-guided fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their structures were elucidated using extensive spectroscopic methods and the modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC(100)) against PANC-1 cells under nutrient-deprived conditions at 1 mu M. Furthermore, both compounds inhibited the migration of PANC-1 cells in the wound closure assay. (C) 2008 Elsevier Ltd. All rights reserved.
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