Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 18, Issue 14, Pages 4033-4037Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.05.115
Keywords
sparfloxacin; quinolones; cobalt(II) complex; interaction with calf-thymus DNA
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The neutral mononuclear cobalt(II) complex with sparfloxacin has been prepared and characterized with physicochemical, spectroscopic and electrochemical techniques and molecular mechanics calculations. The interaction of the complex with calf-thymus DNA has been investigated with UV spectroscopy, cyclic voltammetry and competitive studies with ethidium bromide. The antimicrobial activity of the complex has been tested against three microorganisms. (c) 2008 Elsevier Ltd. All rights reserved.
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