Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 26, Issue 20, Pages 5538-5546Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2018.09.033
Keywords
Depression; 4-Arylpiperazine; 4-Benzylpiperidine; Naphthyl ether; Serotonin reuptake inhibitor; Norepinephrine reuptake inhibitor; Docking
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2012R1A1A2006613]
- Bio & Medical Technology Development Program of the National Research Foundation (NRF)
- Korean government (MSIT) [NRF-2017M3A9G2077568]
Ask authors/readers for more resources
Two series of 4-arylpiperazine- and 4-benzylpiperidine naphthyl ethers were designed based on structure-activity relationship (SAR) and docking model of reported monoamine neurotransmitters reuptake inhibitors. The compounds were synthesized in 3-simple steps and their biological activities were evaluated. Several compounds were proven to be potent inhibitors of serotonin and norepinephrine reuptake. Computer docking was performed to study the interaction of the most potent compound 35 with human serotonin transporter. The results of the analyses suggest that 4-arylpiperazine- and 4-benzylpiperidine naphthyl ethers might be promising anti-depressants worthy of further studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available