Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 18, Issue 5, Pages 1216-1224Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.49241
Keywords
Src-family protein tyrosine kinases; hypertension; coronary heart disease; ischemic heart disease; myocardial ischemia reperfusion injury
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Funding
- National Natural Science Foundation of China [81770360, 81670333]
- Hubei Province Health and Family Planning Scientific Research Project [WJ2019Z004]
- Hubei Provincial Natural Science Foundation of China [2018CFA044]
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SFKs play a crucial role in the development of various cardiovascular diseases by regulating signaling pathways to maintain cardiovascular homeostasis. They have the potential to serve as diagnostic biomarkers and therapeutic targets, paving the way for further clinical applications.
The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases, are ubiquitously expressed in various cell types. Numerous studies have suggested that SFKs are related to signal transduction in major cardiac physiological and pathological processes, it is the activity of SFKs that is connected with the maintenance of cardiovascular homeostasis. Upon stimulation of various injury factors or stress, the phosphorylation state of SFKs is changed, which has been found to modulate different cardiac pathological conditions, such as hypertension, coronary heart disease, ischemic heart disease, myocardial ischemia-reperfusion injury, arrhythmia and cardiomyopathy via regulating cell growth, differentiation, movement and function, electrophysiologic signals. This review summarizes the basic information about SFKs, updates its role in the different processes underlying the development of multiple cardiovascular diseases (CVDs), and highlights their potential role as disease biomarkers and therapeutic targets, which would help understand the pathophysiology of CVDs and promote the further potential clinical adhibition.
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