Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 22, Issue 23, Pages 6586-6594Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2014.10.008
Keywords
3-Aryl-coumarins; Prenylation; Thiocoumarins; Suzuki; Lipoxygenase; Antioxidant
Funding
- NTUA
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In the present project, a series of coumarin analogues, were synthesised and evaluated for their antioxidant and soybean lipoxygenase inhibitory activity. A variety of structural modifications on the coumarin scaffold revealed interesting structure-activity relationships concerning the different biological assays. Prenyloxy-coumarins 9 and 10 displayed the best combined inhibition of lipid peroxidation and soybean lipoxygenase. Thiocoumarins 11 and 14 were identified as potent lipoxygenase inhibitors whereas hydrazone analogues 15 and 16 were efficient DPPH radical scavengers. (C) 2014 Elsevier Ltd. All rights reserved.
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