Journal
LANCET PSYCHIATRY
Volume 8, Issue 2, Pages 121-129Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S2215-0366(20)30491-0
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Funding
- Dutch Research Council [440.20.009]
- Geestkracht programme of the Netherlands Organisation for Health Research and Development [10-000-1002]
- VU University Medical Center
- Geestelijke gezondheidszorg (GGZ) inGeest
- Leiden University Medical Center, Leiden University
- GGZ Rivierduinen
- University Medical Center Groningen
- University of Groningen
- Lentis
- GGZ Friesland
- GGZ Drenthe
- Rob Giel Onderzoekscentrum
- Fonds NutsOhra [0701-065]
- Stichting tot Steun VCVGZ
- NARSAD The Brain and Behaviour Research Fund [41080]
- University Medical Center St Radboud
- GGZ inGeest
- GGNet
- GGZ Nijmegen
- Parnassia
- Academic Department VU Medical Center
- Innova Research Centre
- Mental Health Care Institute GGZ Centraal
- Marina de Wolf Anxiety Research Centre
- Center for Anxiety Disorders Overwaal
- Dimence
- GGZ Overijssel
- Department of Psychiatry at Leiden University Medical Center
- Vincent van Gogh Institute Mental Health Care Centre
- Academic Anxiety Center
- PsyQ Maastricht University
- Division Mental Health and Neuroscience
- Stichting Steun
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The study found that people with depressive, anxiety, or obsessive-compulsive disorders experienced a detrimental impact on their mental health during the COVID-19 pandemic, but there was no further increase in symptom severity. In contrast, individuals without these disorders showed an increase in symptoms during the pandemic.
Background The impact of the COVID-19 pandemic on mental health in people with pre-existing mental health disorders is unclear. In three psychiatry case-control cohorts, we compared the perceived mental health impact and coping and changes in depressive symptoms, anxiety, worry, and loneliness before and during the COVID-19 pandemic between people with and without lifetime depressive, anxiety, or obsessive-compulsive disorders. Methods Between April 1 and May 13, 2020, online questionnaires were distributed among the Netherlands Study of Depression and Anxiety, Netherlands Study of Depression in Older Persons, and Netherlands Obsessive Compulsive Disorder Association cohorts, including people with (n=1181) and without (n=336) depressive, anxiety, or obsessive-compulsive disorders. The questionnaire contained questions on perceived mental health impact, fear of COVID-19, coping, and four validated scales assessing depressive symptoms, anxiety, worry, and loneliness used in previous waves during 2006-16. Number and chronicity of disorders were based on diagnoses in previous waves. Linear regression and mixed models were done. Findings The number and chronicity of disorders showed a positive graded dose-response relation, with greater perceived impact on mental health, fear, and poorer coping. Although people with depressive, anxiety, or obsessive-compulsive disorders scored higher on all four symptom scales than did individuals without these mental health disorders, both before and during the COVID-19 pandemic, they did not report a greater increase in symptoms during the pandemic. In fact, people without depressive, anxiety, or obsessive-compulsive disorders showed a greater increase in symptoms during the COVID-19 pandemic, whereas individuals with the greatest burden on their mental health tended to show a slight symptom decrease. Interpretation People with depressive, anxiety, or obsessive-compulsive disorders are experiencing a detrimental impact on their mental health from the COVID-19 pandemic, which requires dose monitoring in clinical practice. Yet, the COVID-19 pandemic does not seem to have further increased symptom severity compared with their prepandemic levels. Copyright (C) 2020 Elsevier Ltd. All rights reserved.
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