Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 22, Issue 16, Pages 4462-4473Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2014.04.065
Keywords
Benzoxaborole; Oxaborole; Benzoboroxole; Sulfenic acid; Boronic acid
Funding
- Natural Sciences and Engineering Research Council of Canada
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Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date. (C) 2014 Elsevier Ltd. All rights reserved.
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