Journal
CHEMICAL SENSES
Volume 46, Issue -, Pages 1-10Publisher
OXFORD UNIV PRESS
DOI: 10.1093/chemse/bjab011
Keywords
chemotherapy; Hedgehog signaling; Notch signaling; organoids; radiotherapy; Wnt signaling
Funding
- National Institutes of Health/National Institute for Deafness and Other Communication Disorders [R21DC016131, R01DC012383, R01DC018489]
- National Cancer Institute [R21CA236480]
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Although significant progress has been made in cancer therapies since the early 20th century, treatments are often associated with side effects such as taste impairment. This can lead to depression, malnutrition, and weight loss in patients. However, the molecular mechanisms underlying taste disruption in the context of cancer therapies remain poorly understood.
Since the early 20th century, progress in cancer therapies has significantly improved disease prognosis. Nonetheless, cancer treatments are often associated with side effects that can negatively affect patient well-being and disrupt the course of treatment. Among the main side effects, taste impairment is associated with depression, malnutrition, and morbid weight loss. Although relatively common, taste disruption associated with cancer therapies remains poorly understood. Here, we review the current knowledge related to the molecular mechanisms underlying taste maintenance and disruption in the context of cancer therapies.
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