Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 21, Issue 24, Pages 7699-7708Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.10.026
Keywords
Catechols; Biocatalysis; Immobilized tyrosinase; Antiviral; Influenza A virus
Funding
- MIUR [PON01-01802]
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Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties. (C) 2013 Elsevier Ltd. All rights reserved.
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