Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 21, Issue 1, Pages 153-165Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.10.042
Keywords
Glycoconjugated; Porphyrin; Dimers; Two-photon excitation; Phototherapy
Funding
- CNRS
- 'Programme Incitatif et Cooperatif Retinoblastome et Transcriptome' of Institut Curie
- French organization 'Retinostop'
- INCa
- Fondation Pierre-Gilles De Gennes
- Paris-Sud University
- ENS Cachan
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We report the synthesis of bioconjugated zinc porphyrin dimers 1a-e designed as photosensitizers for one-photon and two-photon excited photodynamic therapy. These macrocycles are substituted with carbohydrate units (glucose, mannose, lactose) in order to target tumor cells over-expressing lectin membrane receptors. Polarity, singlet oxygen production and in vitro photocytotoxicity are studied to determine their photodynamic therapy potentiality. (C) 2012 Elsevier Ltd. All rights reserved.
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